M Akiyama Selected Research

Benign Familial Pemphigus (Hailey Hailey Disease)

1/2018	Hailey-Hailey disease due to ATP2C1 splice site mutation, successfully treated with minocycline hydrochloride.
1/2006	Bacterial infection-induced generalized Hailey-Hailey disease successfully treated by etretinate.
7/2001	Upregulation of P-cadherin expression in the lesional skin of pemphigus, Hailey-Hailey disease and Darier's disease.
4/2000	Dissociation of intra- and extracellular domains of desmosomal cadherins and E-cadherin in Hailey-Hailey disease and Darier's disease.

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M Akiyama Research Topics

Disease

6	Atopic Dermatitis (Atopic Eczema) 01/2018 - 08/2009
6	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2017 - 09/2007
5	Bullous Pemphigoid (Pemphigoid) 01/2020 - 11/2000
4	Benign Familial Pemphigus (Hailey Hailey Disease) 01/2018 - 04/2000
4	Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris) 01/2017 - 08/2009
4	Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma) 04/2016 - 02/2001
4	Neoplasms (Cancer) 08/2011 - 03/2000
3	Lamellar Ichthyosis (Harlequin Ichthyosis) 01/2017 - 11/2000
2	Hypotrichosis 09/2021 - 09/2015
2	Dermatomyositis (Dermatopolymyositis) 07/2020 - 01/2017
2	Skin Diseases (Skin Disease) 01/2009 - 09/2002
2	Blister (Bulla) 09/2007 - 10/2003
2	Bacterial Infections (Bacterial Infection) 01/2006 - 05/2005
2	Amyloidosis 03/2005 - 09/2002
2	Pemphigus (Pemphigus Vulgaris) 07/2001 - 04/2000
2	Darier Disease (Darier's Disease) 07/2001 - 04/2000
2	Acantholysis 07/2001 - 04/2000
2	Infections 01/2000 - 01/2000
1	Hidradenitis Suppurativa 01/2020
1	Chondrodysplasia Punctata (Stippled Epiphyses) 11/2018
1	Chilblains (Chilblain) 10/2018
1	Dyschromatosis symmetrica hereditaria 1 10/2018
1	Localized Scleroderma (Morphea) 01/2018
1	Keratitis, Ichthyosis, and Deafness (KID) Syndrome 01/2018
1	Hypohidrosis 01/2018
1	Asthma (Bronchial Asthma) 01/2018
1	Food Hypersensitivity (Food Allergy) 01/2018
1	Eczema 01/2018
1	Amyopathic dermatomyositis 01/2017
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2017
1	Linear IgA Bullous Dermatosis 11/2016
1	Nonepidermolytic Palmoplantar Keratoderma 02/2016
1	Systemic Scleroderma (Systemic Sclerosis) 07/2015
1	Exercise-Induced Allergies 04/2015
1	Hypopigmentation (Hypomelanosis) 04/2015
1	Hyperpigmentation 04/2015
1	Autosomal Recessive Epidermolysis Bullosa Simplex 02/2015
1	Walker-Warburg Syndrome 01/2015
1	Ovarian Neoplasms (Ovarian Cancer) 01/2014
1	Neutropenia 01/2014
1	Ovarian Epithelial Carcinoma 01/2014
1	Febrile Neutropenia 01/2014
1	Melanoma (Melanoma, Malignant) 12/2013
1	Thrombotic Thrombocytopenic Purpura 07/2013
1	Osteoporosis 01/2013

Drug/Important Bio-Agent (IBA)

9	Filaggrin ProteinsIBA 01/2018 - 08/2009
6	AutoantibodiesIBA 01/2020 - 07/2001
4	Proteins (Proteins, Gene)FDA Link 07/2020 - 04/2000
4	AntibodiesIBA 01/2018 - 09/2002
3	DNA (Deoxyribonucleic Acid)IBA 09/2008 - 09/2002
3	Keratins (Keratin)IBA 10/2003 - 01/2000
3	TransglutaminasesIBA 01/2003 - 11/2000
2	Amino Acids FDA Link 10/2018 - 11/2000
2	ConnexinsIBA 01/2018 - 08/2009
2	Pharmaceutical PreparationsIBA 11/2016 - 12/2000
2	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2015 - 09/2007
2	Nonsense Codon (Nonsense Mutation)IBA 02/2015 - 09/2012
2	Protein Isoforms (Isoforms)IBA 02/2015 - 11/2001
2	Collagen Type VIIIBA 09/2007 - 11/2006
2	Immunoglobulin G (IgG)IBA 11/2006 - 01/2000
2	GlucocorticoidsIBA 01/2006 - 11/2001
2	Messenger RNA (mRNA)IBA 05/2005 - 11/2001
2	Cadherins (E-Cadherin)IBA 07/2001 - 04/2000
2	Desmosomal CadherinsIBA 07/2001 - 04/2000
2	Monoclonal AntibodiesIBA 11/2000 - 01/2000
1	Protein Sorting Signals (Signal Peptide)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 11/2018
1	SterolsIBA 11/2018
1	Interleukin-15 (Interleukin 15)IBA 01/2018
1	Minocycline (Cyclops)FDA LinkGeneric 01/2018
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2018
1	Intravenous Immunoglobulins (IVIG)FDA Link 07/2017
1	LipidsIBA 01/2017
1	Keratin-10IBA 04/2016
1	Chemokine CCL17IBA 02/2016
1	Aquaporin 5IBA 02/2016
1	Infliximab (Remicade)FDA Link 10/2015
1	Minoxidil (Rogaine)FDA LinkGeneric 09/2015
1	RNA Polymerase IIIIBA 07/2015
1	Methotrexate (Mexate)FDA LinkGeneric 07/2015
1	Lactate Dehydrogenase 5IBA 06/2015
1	Stem Cell FactorIBA 04/2015
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 04/2015
1	Mitogen-Activated Protein KinasesIBA 04/2015
1	DystoninIBA 02/2015
1	protein O-mannosyltransferase (dolichyl-phosphate-mannose - protein mannosyltransferase)IBA 01/2015
1	Antineoplastic Agents (Antineoplastics)IBA 01/2014
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2014
1	Dacarbazine (DIC)FDA LinkGeneric 12/2013
1	InterferonsIBA 12/2013
1	NimustineIBA 12/2013
1	Vincristine (Oncovin)FDA LinkGeneric 12/2013
1	thiamine triphosphorate (TTP)IBA 07/2013
1	N-formylmethionylphenylalanine (FMP)IBA 01/2013

Therapy/Procedure

5	Therapeutics 09/2021 - 01/2000
2	Blood Component Removal (Apheresis) 12/2017 - 12/2014
2	Drug Therapy (Chemotherapy) 01/2014 - 05/2000
1	Adjuvant Chemotherapy 12/2013
1	Subcutaneous Injections 12/2013
1	Combination Drug Therapy (Combination Chemotherapy) 12/2013